Shares in the Asia-Pacific opened lower Wednesday, following Wall Street’s negative lead ahead of the Federal Reserve’s expected rate hike.The Nikkei 225 in Japan dropped 1.31%, while the Topix index fell 1.23%. In Australia, the S&P/ASX 200 slipped 1.4%.Hong Kong’s Hang Seng index fell 1.25%, and the Hang Seng Tech index dropped 2.1%. In mainland China, the Shanghai Composite lost 0.56% and the Shenzhen Component was 0.9% lower.South Korea’s Kospi declined 0.9%. MCSI’s broadest index of Asia-Pacific shares outside Japan shed around 1%.cnbc.com